Selected References

Virology

Head of Institute:
Prof. Dr. med. Klaus Überla

Selected References

  • Hutterer, C., Hamilton, S., Steingruber, M., Zeitträger, I., Thuma, N., Naing, Z., Örfi, Z., Örfi, L., Socher, E., Sticht, H., Rawlinson, W.D., Chou, S., Haupt, V.J., Marschall, M. (2016). The chemical class of quinazoline compounds provides a core structure for the design of anticytomegaloviral kinase inhibitors. Antiviral Res. 134: 130-43.
  • Milbradt, J., Hutterer, C., Bahsi, H., Wagner, S., Horn, A.H.C., Kaufer, B.B., Mori, Y., Sticht, H., Fossen, F., Marschall, M. (2016). The prolyl isomerase Pin1 promotes the herpesvirus-induced phosphorylation-dependent disassembly of the nuclear lamina required for nucleocytoplasmic egress. PLoS Pathog. 12: e1005825.
  • Steingruber, M., Kraut, A., Socher, E., Sticht, H., Reichel, A., Stamminger, T., Amin, B., Couté, Y., Hutterer, C., Marschall M. (2016). Proteomic interaction patterns between human cyclins, the cyclin-dependent kinase ortholog pUL97 and additional cytomegalovirus proteins. Viruses. 8: doi10.3390/v8080219.
  • Sonntag, E., Hamilton, S.T., Bahsi, H., Wagner, S., Jonjic, S., Rawlinson, W.D., Marschall, M., Milbradt J. (2016). Cytomegalovirus pUL50 is the multi-interacting determinant of the core nuclear egress complex (NEC) that recruits cellular accessory NEC components. J Gen Virol. 97: 1676-85.
  • Hutterer, C., Eickhoff, J., Milbradt, J., Korn, K., Zeitträger, I., Bahsi, H., Wagner, S., Zischinsky, G., Wolf, A., Degenhart, C., Unger, A., Baumann, M., Klebl, B., Marschall, M. (2015). A novel CDK7 inhibitor of the pyrazolo-triazine class exerts broad-spectrum antiviral activity at nanomolar concentrations. Antimicrob Agents Chemother. 59: 2062-71.
  • Steingruber, M., Socher, E., Hutterer, C., Webel, R., Bergbrede, T. Lenac, T., Sticht, H., Marschall, M. (2015). The interaction between cyclin B1 and cytomegalovirus protein kinase pUL97 is determined by an active kinase domain. Viruses. 7: doi10.3390/v7082834.
  • Hutterer, C., Niemann, I., Milbradt, J., Fröhlich, T., Reiter, C., Kadioglu, O., Bahsi, H., Zeitträger, I., Wagner, S., Einsiedel, J., Gmeiner, P., Vogel, N., Wandinger, S., Godl, K., Stamminger, T., Efferth, T., Tsogoeva, S.B., Marschall, M. (2015). The broad-spectrum antiinfective drug artesunate interferes with the canonical nuclear factor kappa B (NF-κB) pathway by targeting RelA/p65. Antiviral Res. 124: 101-9.
  • Walzer, S.A., Egerer-Sieber, C., Sticht, H., Sevvana, M., Hohl, H., Milbradt, M., Muller, Y.A., Marschall, M. (2015). Crystal structure of the human cytomegalovirus pUL50-pUL53 core nuclear egress complex provides insight into a unique assembly scaffold for virus-host protein interactions. J Biol Chem. 290: 27452-8.
  • Milbradt, J., Kraut, A., Hutterer, C., Sonntag, E., Schmeiser, C., Ferro, M., Wagner, S., Lenac, T., Claus, C., Pinkert, S., Hamilton, S.T., Rawlinson, W.D., Sticht, H., Couté, Y., Marschall, M. (2014). Proteomic analysis of the multimeric nuclear egress complex of human cytomegalovirus. Mol Cell Proteomics. 13: 2132-46.
  • Webel, R.*, Hakki, M.*, Prichard, M., Rawlinson, W.D., Marschall, M., Chou, S. (2014). Differential properties of three isoforms of cytomegalovirus protein kinase pUL97 affect viral replication and maribavir susceptibility. J Virol. 88: 4776-85 (*both authors contributed equally).
 
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Summary