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Selected References

Selected References

  • Lagisquet J., Conrad M., Wittmann S., Volkmann B., Weissinger H., Sticht H., Gramberg T. (2023). A frequent SNP in TRIM5a strongly enhances the innate immune response against LINE-1 elements. Front. Immunol. 14:1168589. doi: 10.3389/fimmu.2023.1168589.
  • Schumann T., Ramon S.C., Schubert N., Mayo M.A., Hega M., Maser K.I., Ada S.R., Sydow L., Hajikazemi M., Badstübner M., Müller P., Ge Y., Shakeri F., Buness A., Rupf B., Lienenklaus S., Utess B., Muhandes L., Haase M., Rupp L., Schmitz M., Gramberg T., Manel N., Hartmann G., Zillinger T., Kato H., Bauer S., Gerbaulet A., Paeschke K., Roers A., Behrendt R. (2023). Deficiency for SAMHD1 activates MDA5 in a cGAS/STING-dependent manner. J Exp Med. 220(1):e20220829. doi: 10.1084/jem.20220829.
  • Russ A., Wittmann S., Tsukamoto Y., Herrmann A., Deutschmann J., Lagisquet J., Ensser A., Kato H., Gramberg T. (2022). Nsp16 shields SARS-CoV-2 from efficient MDA5 sensing and IFIT1-mediated restriction. EMBO Rep, 23(12):e55648. doi: 10.15252/embr.202255648. Epub 2022 Oct 26. PMID: 36285486.
  • Bergant V., Yamada S., Grass V., Tsukamoto Y., Lavacca T., Krey K., Mühlhofer M.T., Wittmann S., Ensser A., Herrmann A., Vom Hemdt A., Tomita Y., Matsuyama S., Hirokawa T., Huang Y., Piras A., Jakwerth C.A., Oelsner M., Thieme S., Graf A., Krebs S., Blum H., Kümmerer B.M., Stukalov A., Schmidt-Weber C.B., Igarashi M., Gramberg T., Pichlmair A., Kato H. (2022). Attenuation of SARS-CoV-2 replication and associated inflammation by concomitant targeting of viral and host cap 2'-O-ribose methyltransferases. EMBO J, 41(17): e111608. doi: 10.15252/embj.2022111608.
  • Sure F., Bertog M., Afonso S., Diakov A., Rinke R., Madej M.G., Wittmann S., Gramberg T., Korbmacher C., Ilyaskin A.V. (2022). Transmembrane serine protease 2 (TMPRSS2) proteolytically activates the epithelial sodium channel (ENaC) by cleaving the channel's γ-subunit. J Biol Chem, 298(6): 102004. doi: 10.1016/j.jbc.2022.102004.
  • Deutschmann J., Gramberg T. (2021). SAMHD1 … and Viral Ways around It. Viruses, 13(3): 395. doi: 10.3390/v13030395.
  • Lagisquet J., Zuber K., Gramberg T. (2021). Recognize Yourself-Innate Sensing of Non-LTR Retrotransposons. Viruses, 13(1): 94. doi: 10.3390/v13010094.
  • Bosso M., Prelli Bozzo C., Hotter D., Volcic M., Stürzel C.M., Rammelt A., Ni Y., Urban S., Becker M., Schelhaas M., Wittmann S., Christensen M.H., Schmidt F.I., Gramberg T., Sparrer K.M.J., Sauter D., Kirchhoff F. (2020). Nuclear PYHIN proteins target the host transcription factor Sp1 thereby restricting HIV-1 in human macrophages and CD4+ T cells. PLoS Pathog, 16(8): e1008752. doi: 10.1371/journal.ppat.1008752.
  • Volkmann B., Wittmann S., Lagisquet J., Deutschmann J., Eissmann K., Ross J.J., Biesinger B., Gramberg T. (2020). Human TRIM5α senses and restricts LINE-1 elements. Proc Natl Acad Sci U S A, 117(30): 17965-17976. doi: 10.1073/pnas.1922366117.
  • Deutschmann, J., Schneider, A., Gruska, I., Vetter, B., Thomas, D., Kießling, M., Wittmann, S., Herrmann, A., Schindler, M., Milbradt, J., Ferreirós, N., Winkler, T.H., Wiebusch, L., Gramberg, T. (2019). A viral kinase counteracts in vivo restriction of murine cytomegalovirus by SAMHD1. Nat Microbiol. 2019 Sep 23. doi: 10.1038/s41564-019-0529-z. [Epub ahead of print].
  • Businger, R., Deutschmann, J., Gruska, I., Milbradt, J., Wiebusch, L., Gramberg, T., Schindler, M. (2019). Human cytomegalovirus overcomes SAMHD1 restriction in macrophages via pUL97. Nat Microbiol. 2019 Sep 23. doi: 10.1038/s41564-019-0557-8. [Epub ahead of print].
  • Hotter, D., Bosso, M., Jønsson, K.L., Krapp, C., Stürzel, C.M., Das, A., Littwitz-Salomon, E., Berkhout, B., Russ, A., Wittmann, S., Gramberg, T., Zheng, Y., Martins, L.J., Planelles, V., Jakobsen, M.R., Hahn, B.H., Dittmer, U., Sauter, D., Kirchhoff, F. (2019). IFI16 Targets the Transcription Factor Sp1 to Suppress HIV-1 Transcription and Latency Reactivation. Cell Host Microbe. 25: 858-872.e13.
  • Herrmann, A., Wittmann, S., Shepard, C.N., Thomas, D., Ferreiros, N., Kim, B., Gramberg, T. (2018). The SAMHD1-mediated block of LINE-1 retroelements is regulated by phosphorylation, Mobile DNA. 9: 11.
  • Herrmann, A., Happel, A.U., Gramberg, T. (2016). SAMHD1 in Retroviral Restriction and Innate Immune Sensing--Should We Leash the Hound? Curr HIV Res. 14(3): 225-234.
  • Serra-Moreno, R., Gramberg, T. (2016). Editorial: Strategies to Defeat HIV. Curr HIV Res. 14(3): 173-174.
  • Kahle, T., Volkmann, B., Eissmann, K., Herrmann, A., Schmitt, S., Wittmann, S., Merkel, L., Reuter, N., Stamminger, T., Gramberg, T. (2016). TRIM19/PML Restricts HIV Infection in a Cell Type-Dependent Manner. Viruses. 8(1): 2; doi:10.3390/v8010002.
  • Wittmann, S., Behrendt, R., Eissmann, K., Volkmann, B., Thomas, D., Ebert, T., Cribier, A., Benkirane, M., Hornung, V., Bouzas, N.F., Gramberg, T. (2015). Phosphorylation of murine SAMHD1 regulates its antiretroviral activity. Retrovirology. 12(1): 103.
  • Herzner, A.M., Hagmann, C.A., Goldeck, M., Wolter, S., Kübler, K., Wittmann, S., Gramberg, T., Andreeva, L., Hopfner, K.P., Mertens, C., Zillinger, T., Jin, T., Xiao, T.S., Bartok, E., Coch, C., Ackermann, D., Hornung, V., Ludwig, J., Barchet, W., Hartmann, G., Schlee, M. (2015). Sequence-specific activation of the DNA sensor cGAS by Y-form DNA structures as found in primary HIV-1 cDNA. Nat Immunol. 16(10): 1025-1033.
  • Faissner, S., Ambrosius, B., Schanzmann, K., Grewe, B., Potthoff, A., Münch, J., Sure, U., Gramberg, T., Wittmann, S., Brockmeyer, N., Uberla, K., Gold, R., Grunwald, T., Chan, A. (2014). Cytoplasmic HIV-RNA in monocytes determines microglial activation and neuronal cell death in HIV-associated neurodegeneration. Exp Neurol. 261: 685-697.
  • Behrendt, R., Schumann, T., Gerbaulet, A., Nguyen, L.A., Schubert, N., Alexopoulou, D., Berka, U., Lienenklaus, S., Peschke, K., Gibbert, K., Wittmann, S., Lindemann, D., Weiss, S., Dahl, A., Naumann, R., Dittmer, U., Kim, B., Mueller, W., Gramberg, T., Roers, A. (2013). Mouse SAMHD1 Has Antiretroviral Activity And Suppresses A Spontaneous Cell Intrinsic Antiviral Response, Cell Rep. 4(4): 689-696.
  • Gramberg, T., Kahle, T., Bloch, N., Wittmann, S., Müllers, E., Lindemann, D., Landau, N.R. (2013). Restriction of diverse retroviruses by SAMHD1, Retrovirology. 10: 26.
  • Baldauf, H.M., Pan, X., Erikson, E., Schmidt, S., Daddacha, W., Burggraf, M., Schenkova, K., Ambiel, I., Wabnitz, G., Gramberg, T., Panitz, S., Flory, E., Landau, N.R., Sertel, S., Rutsch, F., Lasitschka, F., Kim, B., König, R., Fackler, O.T., Keppler, O.T. (2012). SAMHD1 restricts HIV-1 infection in resting CD4(+) T cells, Nat Med. 18(11): 1682-1687.
  • Lahouassa, H., Daddacha, W., Hofmann, H., Ayinde, D., Logue, E.C., Dragin, L., Bloch, N., Maudet, C., Bertrand, M., Gramberg, T., Pancino, G., Priet, S., Canard, B., Laguette, N., Benkirane, M., Transy, C., Landau, N.R., Kim, B., Margottin-Goguet, F. (2012). SAMHD1 restricts the replication of human immune-deficiency virus type 1 by depleting the intracellular pool of deoxynucleoside triphosphates, Nat Immunol. 13(3): 223-228.
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