Selected References

Virology

Head of Institute:
Prof. Dr. med. Klaus Überla

Selected References

  • Deutschmann, J., Schneider, A., Gruska, I., Vetter, B., Thomas, D., Kießling, M., Wittmann, S., Herrmann, A., Schindler, M., Milbradt, J., Ferreirós, N., Winkler, T.H., Wiebusch, L., Gramberg, T. (2019). A viral kinase counteracts in vivo restriction of murine cytomegalovirus by SAMHD1. Nat Microbiol. 2019 Sep 23. doi: 10.1038/s41564-019-0529-z. [Epub ahead of print].
  • Businger, R., Deutschmann, J., Gruska, I., Milbradt, J., Wiebusch, L., Gramberg, T., Schindler, M. (2019). Human cytomegalovirus overcomes SAMHD1 restriction in macrophages via pUL97. Nat Microbiol. 2019 Sep 23. doi: 10.1038/s41564-019-0557-8. [Epub ahead of print].
  • Hotter, D., Bosso, M., Jønsson, K.L., Krapp, C., Stürzel, C.M., Das, A., Littwitz-Salomon, E., Berkhout, B., Russ, A., Wittmann, S., Gramberg, T., Zheng, Y., Martins, L.J., Planelles, V., Jakobsen, M.R., Hahn, B.H., Dittmer, U., Sauter, D., Kirchhoff, F. (2019). IFI16 Targets the Transcription Factor Sp1 to Suppress HIV-1 Transcription and Latency Reactivation. Cell Host Microbe. 25: 858-872.e13.
  • Herrmann, A., Wittmann, S., Shepard, C.N., Thomas, D., Ferreiros, N., Kim, B., Gramberg, T. (2018). The SAMHD1-mediated block of LINE-1 retroelements is regulated by phosphorylation, Mobile DNA. 9: 11.
  • Herrmann, A., Happel, A.U., Gramberg, T. (2016). SAMHD1 in Retroviral Restriction and Innate Immune Sensing--Should We Leash the Hound? Curr HIV Res. 14(3): 225-234.
  • Serra-Moreno, R., Gramberg, T. (2016). Editorial: Strategies to Defeat HIV. Curr HIV Res. 14(3): 173-174.
  • Kahle, T., Volkmann, B., Eissmann, K., Herrmann, A., Schmitt, S., Wittmann, S., Merkel, L., Reuter, N., Stamminger, T., Gramberg, T. (2016). TRIM19/PML Restricts HIV Infection in a Cell Type-Dependent Manner. Viruses. 8(1): 2; doi:10.3390/v8010002.
  • Wittmann, S., Behrendt, R., Eissmann, K., Volkmann, B., Thomas, D., Ebert, T., Cribier, A., Benkirane, M., Hornung, V., Bouzas, N.F., Gramberg, T. (2015). Phosphorylation of murine SAMHD1 regulates its antiretroviral activity. Retrovirology. 12(1): 103.
  • Herzner, A.M., Hagmann, C.A., Goldeck, M., Wolter, S., Kübler, K., Wittmann, S., Gramberg, T., Andreeva, L., Hopfner, K.P., Mertens, C., Zillinger, T., Jin, T., Xiao, T.S., Bartok, E., Coch, C., Ackermann, D., Hornung, V., Ludwig, J., Barchet, W., Hartmann, G., Schlee, M. (2015). Sequence-specific activation of the DNA sensor cGAS by Y-form DNA structures as found in primary HIV-1 cDNA. Nat Immunol. 16(10): 1025-1033.
  • Faissner, S., Ambrosius, B., Schanzmann, K., Grewe, B., Potthoff, A., Münch, J., Sure, U., Gramberg, T., Wittmann, S., Brockmeyer, N., Uberla, K., Gold, R., Grunwald, T., Chan, A. (2014). Cytoplasmic HIV-RNA in monocytes determines microglial activation and neuronal cell death in HIV-associated neurodegeneration. Exp Neurol. 261: 685-697.
  • Behrendt, R., Schumann, T., Gerbaulet, A., Nguyen, L.A., Schubert, N., Alexopoulou, D., Berka, U., Lienenklaus, S., Peschke, K., Gibbert, K., Wittmann, S., Lindemann, D., Weiss, S., Dahl, A., Naumann, R., Dittmer, U., Kim, B., Mueller, W., Gramberg, T., Roers, A. (2013). Mouse SAMHD1 Has Antiretroviral Activity And Suppresses A Spontaneous Cell Intrinsic Antiviral Response, Cell Rep. 4(4): 689-696.
  • Gramberg, T., Kahle, T., Bloch, N., Wittmann, S., Müllers, E., Lindemann, D., Landau, N.R. (2013). Restriction of diverse retroviruses by SAMHD1, Retrovirology. 10: 26.
  • Baldauf, H.M., Pan, X., Erikson, E., Schmidt, S., Daddacha, W., Burggraf, M., Schenkova, K., Ambiel, I., Wabnitz, G., Gramberg, T., Panitz, S., Flory, E., Landau, N.R., Sertel, S., Rutsch, F., Lasitschka, F., Kim, B., König, R., Fackler, O.T., Keppler, O.T. (2012). SAMHD1 restricts HIV-1 infection in resting CD4(+) T cells, Nat Med. 18(11): 1682-1687.
  • Lahouassa, H., Daddacha, W., Hofmann, H., Ayinde, D., Logue, E.C., Dragin, L., Bloch, N., Maudet, C., Bertrand, M., Gramberg, T., Pancino, G., Priet, S., Canard, B., Laguette, N., Benkirane, M., Transy, C., Landau, N.R., Kim, B., Margottin-Goguet, F. (2012). SAMHD1 restricts the replication of human immune-deficiency virus type 1 by depleting the intracellular pool of deoxynucleoside triphosphates, Nat Immunol. 13(3): 223-228.
 
Habilitation Prize

Prof. T. Gramberg received on 11/06/2017 the Habilitation Prize of the Faculty of Medicine of the FAU.
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