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Selected References

Selected References

  • Tillmanns, J., Häge, S., Borst, E.B., Wardin, J., Eickhoff, J., Klebl, B., Wagner, S., Wangen, C., Hahn, F., Socher, E. & Marschall, M. (2023). Assessment of covalently binding warhead compounds in the validation of the cytomegalovirus nuclear egress complex as an antiviral target. Cells 12: 1162. doi.org/10.3390/cells12081162.
  • Kicuntod, J., Häge, S., Lösing, J., Kopar, S., Muller, Y.A. & Marschall, M. (2023). An antiviral targeting strategy based on the inducible interference with cytomegalovirus nuclear egress complex. Antiviral Res. 105557. doi: 10.1016/j.antiviral.2023.105557, PMID: 36796541.
  • Hahn, F., Wangen, C., Häge, S., Herrmann, L., Herrmann, A., Tsogoeva, S.B. & Marschall, M. (2023). The trimeric artesunate analog TF27, a broadly acting anti-infective model drug, exerts pronounced anti-SARS-CoV-2 activity spanning variants and host cell types. Pharmaceutics 15: 115, doi.org/10.3390/pharmaceutics15010115, PMID: 36678744.
  • Lösing, J., Häge, S., Schütz, M., Wagner, S., Wardin, J., Sticht, H. & Marschall, M. (2022). 'Shared-hook' and 'changed-hook' binding activities of herpesviral core nuclear egress complexes identified by random mutagenesis. Cells 11: 4030, doi: 10.3390/cells11244030, PMID: 36552794.
  • Alkhashrom, S.*, Kicuntod, J.*, Stillger, K., Lützenburg, T., Anzenhofer, C., Neundorf, I., Marschall, M. & Eichler, J. (2022). A peptide inhibitor of the human cytomegalovirus core nuclear egress complex. Pharmaceuticals 15: 1040, PMID: 36145260 (*contributed equally).
  • Schütz, M., Müller, R., Socher, E., Wangen, C., Full, F., Wyler, E., Wong, D., Scherer, M., Stamminger, T., Chou, S., Rawlinson, W.D., Hamilton, S.T., Sticht, H. & Marschall, M. (2022). Highly conserved interaction profiles between clinically relevant mutants of the cytomegalovirus CDK-like kinase pUL97 and human cyclins: functional significance of cyclin H. Int. J. Mol. Sci. 23: 11814, PMID: 36233116.
  • Häge, S. & Marschall. M. (2022) 'Come together' – the regulatory interaction of herpesviral nuclear egress proteins comprises both essential and accessory functions. REVIEW, Cells 11: 1837, doi: 10.3390/cells11111837, PMID: 35681532.
  • Kicuntod, J., Häge, S., Hahn, F., Sticht, H. & Marschall, M. (2022). The oligomeric assemblies of cytomegalovirus core nuclear egress proteins are associated with host kinases and show sensitivity to antiviral kinase inhibitors. Viruses 14: 1021, doi: 10.3390/v14051021, PMID: 35632762.
  • Wild, M., Hahn, F., Brückner, N., Schütz, M., Wangen, C., Wagner, S., Sommerer, M., Strobl, S. & Marschall, M. (2022). Cyclin-dependent kinases (CDKs) and the human cytomegalovirus-encoded CDK ortholog pUL97 represent highly attractive targets for synergistic drug combinations. Int. J. Mol. Sci. 23: 2493 doi: 10.3390/ijms23052493, PMID: 35269635.
  • Schweininger, J.*, Kriegel, M.*, Häge, S., Conrad, M., Alkhashrom, S., Lösing, J., Weiler, S., Tillmanns, J., Egerer-Sieber, C., Decker, A., Lenac Roviš, T., Eichler, J., Sticht, H., Marschall, M. & Muller, Y. A. (2022). The crystal structure of the varicella-zoster Orf24-Orf27 nuclear egress complex spotlights multiple determinants of herpesvirus subfamily specificity. J. Biol. Chem. 101625, doi: 10.1016/j.jbc.2022.101625, PMID: 35074430 (*contributed equally).
  • Ray, B., Ali, I., Jana, S., Mukherjee, S., Pal, S., Ray, S., Schütz, M. & Marschall, M. (2021). Antiviral strategies using natural source-derived sulfated polysaccharides in the light of the COVID-19 pandemic and major human pathogenic viruses. Viruses 2022, 14: 35, doi.org/10.3390/v14010035, PMID: 35062238.
  • Hahn, F., Hamilton, S.T., Wangen, C., Wild, M., Kicuntod, J., Brückner, N., Follett, J.E.L., Herrmann, L., Kheimar, A., Kaufer, B.B., Rawlinson, W.D., Tsogoeva, S.B. & Marschall, M. (2021). Development of a PROTAC-based targeting strategy provides a mechanistically unique mode of anti-cytomegalovirus activity. Int. J. Mol. Sci., 22: 12858, PMID: 34884662.
  • Häge, S., Büscher, N., Pakulska, V., Hahn, F., Adrait, A., Krauter, S., Borst, E.M., Schlötzer-Schrehardt, U., Couté, Y., Plachter, B. & Marschall, M. (2021). The complex regulatory role of cytomegalovirus nuclear egress protein pUL50 in the production of infectious virus. Cells 10: 3119, PMID: 34831342.
  • Hahn, F., Häge, S., Herrmann, A., Wangen, C., Jungnickl, D., Tillmanns, J., Müller, R., Fraedrich, K., Überla, K., Kohlhof, H., Ensser, A. & Marschall, M. (2021). Methodological development of a multi-readout assay for the assessment of antiviral drugs against SARS-CoV-2. Pathogens 10: 1076, PMID: 34578109.
  • Schütz, M., Steingruber, M., Socher, E., Müller, R., Wagner, S., Kögel, M., Sticht, H. & Marschall, M. (2021). Functional relevance of the interaction between human cyclins and the cytomegalovirus-encoded CDK-like protein kinase pUL97. Viruses 13: 1248, doi.org/10.3390/v13071248, PMID: 34198986.
  • Kicuntod, J., Alkhashrom, S., Häge, S., Diewald, B., Müller, R., Hahn, F., Lischka, P., Sticht, H., Eichler, J. & Marschall, M. (2021). Properties of oligomeric interaction of the cytomegalovirus core nuclear egress complex (NEC) and its sensitivity to an NEC inhibitory small molecule. Viruses 12: 683, PMID: 33799898.
  • Alkhashrom, S., Kicuntod, J., Häge, S., Schweininger, J., Muller, Y.A., Lischka, P., Marschall, M. & Eichler, J. (2021). Exploring the human cytomegalovirus core nuclear egress complex as a novel antiviral target: A new type of small molecule inhibitors. Viruses 13: 471, PMID: 33809234.
  • Häge, S., Sonntag, E., Svrlanska, A., Borst, E.M., Stilp, A.C., Horsch, D., Müller, R., Kropff, B., Milbradt, J., Stamminger, T., Schlötzer-Schrehardt, U. & Marschall, M. (2021). Phenotypical characterization of the nuclear egress of recombinant cytomegaloviruses reveals defective replication upon ORF-UL50 deletion but not pUL50 phosphosite mutation. Viruses 13: 165, doi: 10.3390/v13020165, PMID: 33499341.
  • Wild, M., Kicuntod, J., Seyler, L., Wangen, C., Bertzbach, L.D., Conradie, A.M., Kaufer, B.B., Wagner, S., Michel, D., Eickhoff, J., Tsogoeva, S.B., Bäuerle, T., Hahn, F., Marschall, M. (2021). Combinatorial drug treatments reveal promising anticytomegaloviral profiles for clinically relevant pharmaceutical kinase inhibitors (PKIs). Int. J. Mol. Sci. 22: E575, doi: 10.3390/ijms22020575, PMID: 33430060.
  • Hahn, F., Wangen, C., Häge, S., Peter, A.S., Dobler, G., Hurst, B., Julander, J., Fuchs, J., Ruzsics, Z., Überla, K., Jäck, H.M., Ptak, R.G., Muehler, A., Gröppel, M., Vitt, D., Peelen, E., Kohlhof, H. & Marschall, M. (2020). IMU-838, a developmental DHODH inhibitor in phase II for autoimmune disease, shows anti-SARS-CoV-2 and broad-spectrum antiviral efficacy in vitro. Viruses 12, 1394, doi: 10.3390/v12121394, PMID: 33291455.
  • Wild, M., Hahn, F., Grau, B., Herrmann, L., Niesar, A., Schütz, M., Lorion, M.M., Ackermann, L., Tsogoeva, S.B. & Marschall, M. (2020). The artemisinin-derived autofluorescent compound BG95 exerts strong anticytomegaloviral activity based on a mitochondrial targeting mechanism. Int. J. Mol. Sci. 21: 5578, doi 10.3390/ijms21155578, PMID: 32759737.
  • Hahn, F., Niesar, A., Wangen, C., Wild, M., Grau, B., Herrmann, L., Capci, A., Adrait, A., Couté, Y., Tsogoeva, S.B. & Marschall, M. (2020). Target verification of artesunate-related antiviral drugs: assessing the role of mitochondrial and regulatory proteins by click chemistry and fluorescence labeling. Antiviral Res. 104861, doi: 10.1016/j.antiviral.2020.104861, PMID: 32590041.
  • Häge, S., Horsch, D., Stilp, A.C., Kicuntod, J., Müller, R., Hamilton, S.T., Egilmezer, E., Rawlinson, W.D., Stamminger, T., Sonntag, E. & Marschall, M. (2020). A quantitative nuclear egress assay to investigate the nucleocytoplasmic capsid release of human cytomegalovirus. J. Virol. Methods 283: 113909, doi: 10.1016/j.jviromet.2020.113909, PMID: 32544419.
  • Couté, Y., Kraut, A., Zimmermann, C., Büscher, N., Hesse, A.M., Bruley, C., De Andrea, M., Wangen, C., Hahn, F., Marschall, M. & Plachter, B. (2020). Mass spectrometry-based characterization of the virion proteome, phosphoproteome, and associated kinase activity of human cytomegalovirus. REVIEW, Microorganisms 8: 820, doi: 10.3390/microorganisms8060820, PMID: 32486127.
  • Schütz, M., Thomas, M.*, Wangen, C., Wagner, S., Rauschert, L., Errerd, T., Kießling, M., Sticht, H., Milbradt, J.* & Marschall, M. (2020). The peptidyl-prolyl cis/trans isomerase Pin1 interacts with three early regulatory proteins of human cytomegalovirus. Virus Res. 285: 198023, doi: 10.1016/j.viruses.2020.198023, PMID: 32428517 (*contributed equally).
  • Wild, M., Bertzbach, L.D., Tannig, P., Wangen, C., Müller, R., Herrmann, L., Fröhlich, T., Tsogoeva, S.B., Kaufer, B.B., Marschall, M. & Hahn, F. (2020). The trimeric artesunate derivative TF27 exerts strong anti-cytomegaloviral efficacy: focus on prophylactic efficacy and oral treatment of immunocompetent mice. Antiviral Res. 178: 104788, doi: 10.1016/j.antiviral.2020.104788, PMID: 32251769.
  • Marschall, M., Häge, S.*, Conrad, M.*, Alkhashrom, S.*, Kicuntod, J., Schweininger, J., Kriegel, M., Lösing, J., Tillmanns, J., Neipel, F., Eichler, J., Muller, Y.A. & Sticht, H. (2020). Nuclear egress complexes of HCMV and other herpesviruses: solving the puzzle of sequence coevolution, conserved structures and subfamily-spanning binding properties. REVIEW, Viruses 12, 683, doi:10.3390/v12060683, PMID: 32599939 (*contributed equally).
  • Steingruber M. & Marschall, M. (2020). The cytomegalovirus protein kinase pUL97: host interactions, regulatory mechanisms and antiviral drug targeting. REVIEW, Microorganisms 8, 515, doi: 10.3390/microorganisms8040515, PMID: 32260430.
  • Häge, S., Sonntag, E., Borst, E.M., Tannig, P., Seyler, L., Bäuerle, T., Bailer, S.M., Lee, C.P., Müller, R., Wangen, C., Milbradt, J. & Marschall, M. (2020). Patterns of autologous and nonautologous interactions between core nuclear egress complex (NEC) proteins of α-, β- and γ-herpesviruses. Viruses 12, 303, doi:10.3390/v12030303, PMID: 32168891.
  • Muller, Y.A., Häge, S., Alkhashrom, S., Höllriegl, T., Weigert, S., Dolles, S., Hof, K., Walzer, S.A., Egerer-Sieber, C., Conrad, M., Holst, S., Lösing, J., Sonntag, E., Sticht, H., Eichler, J. & Marschall, M. (2020). High-resolution crystal structures of two prototypical β- and γ-herpesviral nuclear egress complexes unravel the determinants of subfamily specificity. J. Biol. Chem. pii: jbc.RA119.011546, doi: 10.1074/jbc.RA119.011546, PMID: 31980459.
  • Thomas, M., Müller, R., Horn, G., Bogdanow, B., Imami, K., Milbradt, J., Steingruber, M., Marschall, M., Schilling, E.M., Fossen, T. & Stamminger, T. (2020). Phosphosite analysis of the cytomegaloviral mRNA export factor pUL69 reveals serines with critical importance for recruitment of cellular proteins Pin1 and UAP56/URH49. J. Virol. pii: JVI.02151-19, doi: 10.1128/JVI.02151-19, PMID: 31969433.
  • Marschall, M., Strojan, H., Kiener, R., Wangen, C., Sonntag, E., Müller, R., Zeitträger, I., Wagner, S., Stamminger, T., Milbradt, J., Behrends, U., Körber, N., Bauer, T., Schrödel, S., Thirion, C., Wagner, R. & Hutterer, C. (2020). Differential upregulation of host cell protein kinases by the replication of a-, b- and g-herpesviruses in human fibroblasts provides a signature of virus-specific signaling. J. Gen. Virol., doi: 10.1099/jgv.0.001370, PMID: 31958050.
  • Cazorla-Vázquez, S., Steingruber, M., Marschall, M. & Engel, F.B. (2019). Cytomegalovirus kinase pUL97 dysregulates early embryonic development in a zebrafish model. Sci. Rep. 9, 7219, doi.org/10.1038/s41598-019-43649-x, PMID: 31076608.
  • Steingruber, M., Keller, L., Socher, E., Ferre, S., Hesse, A.M., Couté, Y., Hahn, F., Büscher, N., Plachter, B., Sticht, H. & Marschall, M. (2019). Cyclins B1, T1 and H differ in their molecular mode of interaction with cytomegalovirus protein kinase pUL97. J. Biol. Chem. 294: 6188-6203, PMID: 30782840.
  • Sonntag, E., Hahn, F., Bertzbach, L.D., Seyler, L., Wangen, C., Tannig, P., Grau, B., Baumann, M., Zent, E., Zischinsky, G., Eickhoff, J., Kaufer, B., Bäuerle, T., Tsogoeva, S. & Marschall, M. (2019). In vivo proof-of-concept for two experimental antiviral drugs, both directed to cellular targets, using a murine cytomegalovirus model. Antiviral Res. 161: 63-69, PMID: 30452929.
  • Hahn, F.*, Hutterer, C.*, Henry, C.*, Hamilton, S.T., Strojan, H., Kraut, A., Schulte, U., Schütz, M., Kohrt, S., Wangen, C., Pfizer, J., Couté, Y., Rawlinson, W.D., Strobl, S. & Marschall, M. (2018). Novel cytomegalovirus-inhibitory compounds of the class pyrrolopyridines show a complex pattern of target binding that suggests an unusual mechanism of antiviral activity. Antiviral Res. 159: 84-94, PMID: 30268914 (*contributed equally).
  • Hahn, F.*, Fröhlich, T.*, Frank, T., Bertzbach, L.D., Kohrt, S., Kaufer, B.B., Stamminger, T., Tsogoeva, S.B. & Marschall, M. (2018). Artesunate-derived monomeric, dimeric and trimeric experimental drugs – their unique mechanistic basis and pronounced antiherpesviral activity. Antiviral Res. 152: 104–110, PMID: 29458133 (*contributed equally).
  • Held, F.E., Guryev, A.A., Fröhlich, T., Hampel, F., Kahnt, A., Hutterer, C., Steingruber, M., Bahsi, H., von Bojničić-Kninski, C., Mattes, D.S., Foertsch, T.C., Nesterov-Mueller, A., Marschall, M. & Tsogoeva, S.B. (2017). Facile access to novel antiviral quinazoline heterocycles with fluorescence properties via merging metal-free domino reactions. Nature Comm. 8: 15071, doi: 10.1038/ncomms15071, PMID: 28462939.
  • Marschall, M.*, Muller, Y.A.*, Diewald, B., Sticht, H.* & Milbradt, J.* (2017). The human cytomegalovirus nuclear egress complex unites multiple functions: recruitment of effectors, nuclear envelope rearrangement and docking to nuclear capsids. REVIEW, Rev. Med. Virol. 27: e1934, PMID: 28664574 (*contributed equally).
  • Hutterer, C., Hamilton, S., Steingruber, M., Zeitträger, I., Thuma, N., Naing, Z., Örfi, Z., Örfi, L., Socher, E., Sticht, H., Rawlinson, W.D., Chou, S., Haupt, V.J. & Marschall, M. (2016). The chemical class of quinazoline compounds provides a core structure for the design of anticytomegaloviral kinase inhibitors. Antiviral Res. 134: 130-143, PMID: 27515131.
  • Walzer, S.A., Egerer-Sieber, C., Sticht, H., Sevvana, M., Hohl, H., Milbradt, J., Muller, Y.A. & Marschall, M. (2015). Crystal structure of the human cytomegalovirus pUL50-pUL53 core nuclear egress complex provides insight into a unique assembly scaffold for virus-host protein interactions. J. Biol. Chem. 290: 27452-27458, PMID: 26432641.
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