Selected References

Virology

Head of Institute:
Prof. Dr. med. Klaus Überla

Selected References

  • Sonntag, E., Hahn, F., Bertzbach, L.D., Seyler, L., Wangen, C., Tannig, P., Grau, B., Baumann, M., Zent, E., Zischinsky, G., Eickhoff, J., Kaufer, B., Bäuerle, T., Tsogoeva, S., Marschall, M. (2019). In vivo proof-of-concept for two experimental antiviral drugs, both directed to cellular targets, using a murine cytomegalovirus model. Antiviral Res. 161: 63-69.
  • Hamilton, S., Hutterer, H., Egilmezer, E., Steingruber, M., Milbradt, J., Marschall, M., Rawlinson, W. (2018). Human cytomegalovirus utilises cellular dual-specificity tyrosine phosphorylation-regulated kinases during placental replication. Placenta. 72-73: 10-19, doi: 10.1016.
  • Hahn, F.*, Hutterer, C.*, Henry, C.*, Hamilton, S.T., Strojan, H., Kraut, A., Schulte, U., Schütz, M., Kohrt, S., Wangen, C., Pfizer, J., Couté, C., Rawlinson, W.D., Strobl, S., Marschall, M. (2018). Novel cytomegalovirus-inhibitory compounds of the class pyrrolopyridines show a complex pattern of target binding that suggests an unusual mechanism of antiviral activity. Antiviral Res. 159: 84-94 (*contributed equally).
  • Fröhlich, T.*, Hahn, F.*, Belmudes, L., Leidenberger, M., Friedrich, O., Kappes, B., Couté, Y., Marschall, M., Tsogoeva, S.B. (2018). Synthesis of artemisinin-derived dimers, trimers and dendrimers: investigation of their antimalarial and antiviral activities including putative mechanisms of action. Chem Eur J. 24: 8103-8113 (*contributed equally).
  • Hahn, F.*, Fröhlich, T.*, Frank, T., Bertzbach, L.D., Kohrt, S., Kaufer, B.B., Stamminger, T., Tsogoeva, S.B., Marschall, M. (2018). Artesunate-derived monomeric, dimeric and trimeric experimental drugs – their unique mechanistic basis and pronounced antiherpesviral activity. Antiviral Res. 152: 104–110 (*contributed equally).
  • Milbradt, J., Sonntag, E., Wagner, S., Strojan, H., Wangen, C., Lenac Rovis, T., Lisnic, B., Jonjic, S., Sticht, H., Britt, W.J., Schlötzer-Schrehardt, U., Marschall, M. (2018). Human cytomegalovirus nuclear capsids associate with the core nuclear egress complex and the viral protein kinase pUL97. Viruses. 10, doi: 10.3390/v10010035.
  • Marschall, M.*, Muller, Y.A.*, Diewald, B., Sticht, H.*, Milbradt, J.* (2017). The human cytomegalovirus nuclear egress complex unites multiple functions: recruitment of effectors, nuclear envelope rearrangement and docking to nuclear capsids. Rev Med Virol. 27: e1934 (*contributed equally).
  • Sonntag, E., Milbradt, J., Svrlanska, A., Strojan, H., Häge, S., Kraut, A., Hesse, A.M., Amin, B., Sonnewald, U., Couté, Y., Marschall, M. (2017). Protein kinases responsible for the phosphorylation of the nuclear egress core complex of human cytomegalovirus. J Gen Virol. 98: 2569-2581.
  • König, P.*, Büscher, N.*, Steingruber, M., Socher, E., Sticht, H., Tenzer, S., Plachter, B., Marschall, M. (2017). Dynamic regulatory interaction between cytomegalovirus major tegument protein pp65 and protein kinase pUL97 in intracellular compartments, dense bodies and virions. J Gen Virol. 98: 2850-2863, doi: 10.1099/jgv.0.000939 (*contributed equally).
  • Hutterer, C., Milbradt, J., Hamilton, S., Zaja, M., Leban, J., Henry, C., Vitt, D., Steingruber, M., Sonntag, E., Zeitträger, I., Bahsi, H., Stamminger, T., Rawlinson, W.D., Strobl, S., Marschall, M. (2017). Inhibitors of dual-specificity tyrosine phosphorylation-regulated kinases (DYRK) exert a strong anti-herpesviral activity. Antiviral Res. 143: 113-121.
  • Held, F.E., Guryev, A.A., Fröhlich, T., Hampel, F., Kahnt, A., Hutterer, C., Steingruber, M., Bahsi, H., von Bojničić-Kninski, C., Mattes, D.S., Foertsch, T.C., Nesterov-Mueller, A., Marschall, M., Tsogoeva, S.B. (2017). Facile access to novel antiviral quinazoline heterocycles with fluorescence properties via merging metal-free domino reactions. Nat Comm. 8: 15071, doi: 10.1038/ncomms15071.
  • Biolatti, M., Dell’Oste, V., Pautasso, S., von Einem, J., Marschall, M., Plachter, B., Gariglio, M., De Andrea, M., Landolfo, S. (2016). Regulatory interaction between the cellular restriction factor IFI16 and viral pp65 (pUL83) modulates viral gene expression and IFI16 protein stability. J Virol. 90: 8238-8250.
  • Hutterer, C., Hamilton, S., Steingruber, M., Zeitträger, I., Thuma, N., Naing, Z., Örfi, Z., Örfi, L., Socher, E., Sticht, H., Rawlinson, W.D., Chou, S., Haupt, V.J., Marschall, M. (2016). The chemical class of quinazoline compounds provides a core structure for the design of anticytomegaloviral kinase inhibitors. Antiviral Res. 134: 130-143.
  • Milbradt, J., Hutterer, C., Bahsi, H., Wagner, S., Horn, A.H.C., Kaufer, B.B., Mori, Y., Sticht, H., Fossen, F., Marschall, M. (2016). The prolyl isomerase Pin1 promotes the herpesvirus-induced phosphorylation-dependent disassembly of the nuclear lamina required for nucleocytoplasmic egress. PLoS Pathog. 12: e1005825.
  • Steingruber, M., Kraut, A., Socher, E., Sticht, H., Reichel, A., Stamminger, T., Amin, B., Couté, Y., Hutterer, C., Marschall, M. (2016). Proteomic interaction patterns between human cyclins, the cyclin-dependent kinase ortholog pUL97 and additional cytomegalovirus proteins. Viruses. 8, doi: 10.3390/v8080219.
  • Sonntag, E., Hamilton, S.T., Bahsi, H., Wagner, S., Jonjic, S., Rawlinson, W.D., Marschall, M., Milbradt, J. (2016). Cytomegalovirus pUL50 is the multi-interacting determinant of the core nuclear egress complex (NEC) that recruits cellular accessory NEC components. J Gen Virol. 97: 1676-1685.
  • Hutterer, C., Eickhoff, J., Milbradt, J., Korn, K., Zeitträger, I., Bahsi, H., Wagner, S., Zischinsky, G., Wolf, A., Degenhart, C., Unger, A., Baumann, M., Klebl, B., Marschall, M. (2015a). A novel CDK7 inhibitor of the pyrazolo-triazine class exerts broad-spectrum antiviral activity at nanomolar concentrations. Antimicrob Agents Chemother. 59: 2062-2071.
  • Steingruber, M., Socher, E., Hutterer, C., Webel, R., Bergbrede, T., Lenac, T., Sticht, H., Marschall, M. (2015). The interaction between cyclin B1 and cytomegalovirus protein kinase pUL97 is determined by an active kinase domain. Viruses. 7, doi: 10.3390/v7082834.
  • Hutterer, C., Niemann, I., Milbradt, J., Fröhlich, T., Reiter, C., Kadioglu, O., Bahsi, H., Zeitträger, I., Wagner, S., Einsiedel, J., Gmeiner, P., Vogel, N., Wandinger, S., Godl, K., Stamminger, T., Efferth, T., Tsogoeva, S.B., Marschall, M. (2015b). The broad-spectrum antiinfective drug artesunate interferes with the canonical nuclear factor kappa B (NF-kB) pathway by targeting RelA/p65. Antiviral Res. 124: 101-109.
  • Walzer, S.A., Egerer-Sieber, C., Sticht, H., Sevvana, M., Hohl, H., Milbradt, M., Muller, Y.A., Marschall, M. (2015). Crystal structure of the human cytomegalovirus pUL50-pUL53 core nuclear egress complex provides insight into a unique assembly scaffold for virus-host protein interactions. J Biol Chem. 290: 27452-27458.