Selected References

Virology

Head of Institute:
Prof. Dr. med. Klaus Überla

Selected References

  • Schmalen, A., Karius-Fischer, J., Rauch, P., Setz, C., Korn, K., Henklein, P., Fossen, T., Schubert, U. (2018). The N-Terminus of the HIV-1 p6 Gag Protein Regulates Susceptibility to Degradation by IDE. Viruses. 10: 710.
  • Agarwal, N., Iyer, D., Gabbi, C., Saha, P., Patel, S.G., Mo, Q., Chang, B., Goswami, B., Schubert, U., Kopp, J.B., Lewis, D.E., Balasubramanyam, A. (2017). HIV-1 viral protein R (Vpr) induces fatty liver in mice via LXRα and PPARα dysregulation: implications for HIV-specific pathogenesis of NAFLD. Sci Rep. 7(1): 13362.
  • Setz, C., Friedrich, M., Rauch, P., Fraedrich, K., Matthaei, A., Traxdorf, M., Schubert, U. (2017). Inhibitors of Deubiquitinating Enzymes Block HIV-1 Replication and Augment the Presentation of Gag-Derived MHC-I Epitopes. Viruses. 9(8): 222.
  • Hahn, F., Schmalen, A., Setz, C., Friedrich, M., Schlößer, S., Kölle, J., Spranger, R., Rauch, P., Fraedrich, K., Reif, T., Karius-Fischer, J., Balasubramanyam, A., Henklein, P., Fossen, T., Schubert, U. (2017). Proteolysis of mature HIV-1 p6 Gag protein by the insulin-degrading enzyme (IDE) regulates virus replication in an Env-dependent manner. PLoS One. 12(4): e0174254.
  • Greiner, T., Bolduan, S., Hertel, B., Groß, C., Hamacher, K., Schubert, U., Moroni, A., Thiel, G. (2016). Ion Channel Activity of Vpu Proteins Is Conserved throughout Evolution of HIV-1 and SIV. Viruses. 8(12).
  • Friedrich, M., Setz, C., Hahn, F., Matthaei, A., Fraedrich, K., Rauch, P., Henklein, P., Traxdorf, M., Fossen, T., Schubert, U. (2016). Glutamic Acid Residues HIV-1 p6 Regulate Virus Budding and Membrane Association of Gag. Viruses. 8(4).
  • Hahn, F., Setz, C., Friedrich, M., Rauch, P., Solbak, S.M., Froystein, N.A., Henklein, P., Votteler, J., Fossen, T., Schubert, U. (2014). Mutation of the highly conserved Ser-40 of the HIV-1 p6 Gag protein to Phe causes the formation of a hydrophobic patch, enhances membrane association, and polyubiquitination of Gag. Viruses. 6: 3738-3765.
  • Bolduan, S., Reif, T., Schindler, M., Schubert, U. (2014). HIV-1 Vpu mediated downregulation of CD155 requires alanine residues 10, 14 and 18 of the transmembrane domain. Virology. 464-465C: 375-384.
  • Bolduan, S., Hubel, P., Reif, T., Lodermeyer, V., Höhne, K., Fritz, J.V., Sauter, D., Kirchhoff, F., Fackler, O.T., Schindler, M., Schubert, U. (2013). HIV-1 Vpu affects the anterograde transport and the glycosylation pattern of NTB-A. Virology 440(2): 190-203.
  • Agarwal, N., Iyer, D., Patel, S.G., Sekhar, R.V., Phillips, T.M., Schubert, U., Oplt, T., Buras, E.D., Samson, S.L., Couturier, J., Lewis, D.E., Rodriguez-Barradas, M.C., Jahoor, F., Kino, T., Kopp, J.B., Balasubramanyam, A. (2013). HIV-1 Vpr induces adipose dysfunction in vivo through reciprocal effects on PPAR/GR co-regulation. Sci Transl Med. 5(213).