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Project B3: Moritz Schmiedeberg, associated doctoral researcher (PhD)

Vaccine-induced immunity in HIV exposed-uninfected infants

A growing number of newborns are exposed to HIV in utero. Although not infected, these HIV-exposed uninfected infants still have a higher risk of severe infections, infection-related hospitalizations, and death compared to HIV-unexposed uninfected infants. In Sub-Saharan Africa, that has the majority of persons living with HIV, infants are recurrently at risk for various illnesses. This project seeks to unravel the immunological impact of recurrent childhood infections in HIV-exposed uninfected infants and to assess effects on vaccine immune responses. This DFG-funded project takes place in Cameroon in collaboration with Dr. Livo Esemu and Dr. Micheal Besong.